What's special about cannabigerol products?
Considering the effectiveness of using cannabigerol products with significant therapeutic potential, as well as the commercialization of the use of cannabigerol raw materials in our country, most likely, within a not very long period of time, products will appear in Ukraine, the composition of the recipe of which will include cannabigerol of plant origin of national production.
It is well known that cannabigerol ( CBG ) and its precursor
before decarboxylation, cannabigerolic acid, are called the "mother of all
cannabinoids". Given the fact that a variety rich in this non-narcotic
cannabinoid is being registered in Ukraine, the editors of the specialized electronic
publication of national hemp growers asked the originators of the variety, as
well as representatives of companies that conducted research to determine the
effectiveness of cannabigerol raw materials, what features of use were noted
during the use of cannabigerol products. Traditionally, the information
provided is published without any changes or cuts.
A Brief
History of the Discovery and Research of Cannabigerol
The maximum amount of
cannabigerol ( CBG ), along with its parent compound
cannabigerolic acid ( CBGA ), is found in “raw” cannabis before
decarboxylation under the influence of various external factors (heat, light,
aging, etc.). CBG was
isolated and structurally characterized in 1964 as “the missing link in the
plant synthesis of cannabinoid components.” Cannabigerol was
synthesized by its discoverers in 1971, after which research into this compound
died down for decades. Research into the medicinal properties of plant
cannabigerol was only resumed in the 21st century.
Cannabigerol Research
Naturally, before using
cannabigerol raw materials, the results of studies concerning cannabigerol
conducted by our foreign colleagues were studied. In particular, the following
data were processed:
• According to a 2015 study in mice, CBG shows
potential as a neuroprotectant in Huntington's disease and may be useful in
other neurodegenerative diseases;
• A 2018 study found that CBG may reduce inflammation, oxidative stress,
and the expansion of certain proteins associated with neuroinflammation;
• A 2014 study found that CBG may reduce the growth of cancer cells and
other tumors, and experiments in 2018 showed that CBG can
inhibit the growth of cancer cells and slow the progression of the disease. In
a 2021 study, CBG inhibited
the invasion of glioblastoma (a very aggressive cancer) in a similar way to CBD and the
chemotherapy drug temozolomide;
• A 2008 study suggests that CBG may reduce intraocular pressure due to its
vasodilatory properties and also has neuroprotective effects. These effects may
reduce problems caused by glaucoma;
• research shows that CBG may be an effective antibacterial agent
against methicillin-resistant Staphylococcus aureus ( MRSA ), which
causes drug-resistant staph infections;
• A 2015 study looked at how five different cannabinoids affect
the bladder and found that CBG shows the most promise in treating bladder
dysfunction;
• A 2013 study in mice showed that CBG may be
beneficial for inflammatory bowel disease;
• CBG is a 5- HTA 1 serotonin receptor antagonist and is being
studied for the treatment of SSRI-induced sexual dysfunction ( PSSD );
• Two studies conducted in 2016 and 2018 show that CBG may
modify eating behavior during depletion.
National experience of using
cannabigerol raw materials
Having received a small amount of cannabigerol raw materials back in 2023 as a result of work on the creation of a cannabigerol variety, several products were manufactured, the methods of administration to the subjects' bodies of which ranged from oral to topical or sublingual use. That is, cannabigerol raw materials were effectively used in the composition of food formulations, cosmetics, topical agents, and various types of additives.
The results obtained from the use of cannabigerol raw materials can be characterized as follows:
- it can be effectively used to
relieve various symptoms or treat a number of serious, including chronic,
diseases;
- it is more appropriate to use
it compared to traditionally used drugs.
It should be noted initially
that, whenever possible, the subjects were provided with fresh leaves and
inflorescences of the cannabigerol variety being created, due to the fact that
the maximum amount of therapeutically active substances was found in the
freshly cut “green mass” of hemp plants. Another option for using cannabigerol
raw materials was the use of various types of cannabigerol products
manufactured using cannabigerol hydrolysate or full-spectrum extract in the
recipe.
The effectiveness of using
cannabigerol to relieve various symptoms or treat a number of severe, including
chronic, diseases
Most often, consumers of
cannabigerol products noted a positive effect on their body in solving problems
with: anxiety, chronic pain, depression, insomnia or sleep disorders, various
types of inflammation, and autoimmune diseases. Positive dynamics were indicated
during the use of plant-based cannabigerol for the relief of headaches,
menstrual pain, problems associated with endometriosis, Crohn's disease,
ulcerative colitis, irritable bowel syndrome, as an
antiseptic/antifungal/antibiotic agent, as well as in the treatment of various
types of oncological diseases. Representatives of the control groups focused on
the effectiveness of using cannabigerol products to reduce arterial
and intraocular pressure, as well as for the treatment of psoriasis. The
overwhelming majority of subjects noted that regular use of cannabigerol
products contributed to the improvement of their general well-being, as well as
the range of sexual sensations.
Appropriateness of use in
comparison with traditionally used drugs
A significant proportion of
test group participants preferred cannabigerol products over conventional
medications for chronic pain, acute pain, insomnia/sleep disorders,
migraines/headaches, nausea, irritable bowel syndrome, autoimmune diseases,
anxiety and depression, and various types of inflammation,
Commentary from experts of the
Association “Ukrainian Industrial Hemp”
Considering the effectiveness of using cannabigerol products with significant therapeutic potential, as well as the commercialization of the use of cannabigerol raw materials in our country, most likely, within a not very long period of time, products will appear in Ukraine, the composition of the recipe of which will include cannabigerol of plant origin of national production.
